Methylmalonic acid in autism |
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Methylmalonic acid (seen here as the Coenzyme A form)
as a compound that is broken down through the succinate fraction of the Krebs
cycle. |
Single reportThis was simply reported by one group but in a high proportion of autistic children that were tested. However, the work has not been repeated although it would seem to be a reasonable thing to do at a later date. It is produced by fatty acid chain breakdown and from gut flora, but the body generally destroys it such that only small amounts are found in the urine. |
Methylmalonic Acid
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet. 1998 Feb 28;351(9103):637-41. Abnormal laboratory results were significantly raised urinary methylmalonic acid compared with age-matched controls (p=0.003). This has neither been repeated nor interpreted adequately
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